The sentinel node biopsy in early gastric cancer: a preliminary study.
Langenbecks Arch Surg
; 391(2): 113-7, 2006 Apr.
Article
en En
| MEDLINE
| ID: mdl-16525854
ABSTRACT
BACKGROUND AND AIMS:
Sentinel node biopsy is currently used in surgery of malignant melanoma and breast cancer. The feasibility of sentinel node mapping in gastrointestinal cancers and its diagnostic sensitivity is unclear. It could be of particular value in the management of early gastric cancer in which radical D2 lymphadenectomy may be unnecessary. MATERIALS ANDMETHODS:
From January 2004 to June 2005, ten patients with preoperative diagnosis of early gastric cancer and no nodal involvement (cT1N0) were submitted to sentinel node biopsy using the dual mapping procedure with endoscopic blue dye and 99mTc radio colloid injection. All the patients underwent standard radical gastrectomy and D2 lymphadenectomy. The resected nodes were evaluated by routine (hematoxylin-eosin) histopathological examination; the sentinel (blue or hot) nodes, in addition, were evaluated with immunohistochemistry for cytokeratin.RESULTS:
The detection rate of this procedure was 100%. The preliminary results and perspectives for feasibility of sentinel node biopsy and its accuracy in predicting the nodal status in early gastric cancer are discussed.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Biopsia del Ganglio Linfático Centinela
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Langenbecks Arch Surg
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia