Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.
Ann Hepatol
; 5(1): 56-9, 2006.
Article
en En
| MEDLINE
| ID: mdl-16531969
ABSTRACT
Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity. Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta. We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.
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Bases de datos:
MEDLINE
Asunto principal:
Adyuvantes Inmunológicos
/
Interferón beta
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Hepatopatías
/
Esclerosis Múltiple
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Ann Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos