Antibiotics-induced acute interstitial nephritis in 6 children.
Urol Int
; 76(4): 348-52, 2006.
Article
en En
| MEDLINE
| ID: mdl-16679839
ABSTRACT
INTRODUCTION:
Antibiotics-induced acute interstitial nephritis (AIN) is a rare disorder in children, and the diagnosis is often delayed. However, many commonly prescribed antibiotics seem to be implicated. PATIENTS ANDMETHODS:
We reviewed the medical records of 6 children, age range from 10 months to 14 years, with biopsy-confirmed antibiotics-induced AIN. Clinical presentation, morphological findings, and outcomes are reported.RESULTS:
Symptoms of AIN started 2-4 weeks after antimicrobial therapy with beta-lactam antibiotics in 5 children and with gentamicin in 1 child. All patients presented with acute renal failure and fever. The glomerular filtration rate was dramatically reduced in 2 cases and mildly reduced in 4 patients. Two of our patients had supportive treatment, 2 received corticosteroid therapy, and 2 children remained under peritoneal dialysis for 12 and 22 days, respectively. Five patients had a full recovery of their renal function, and 1 child, 2 years later, still presented impairment of the renal function.CONCLUSION:
AIN should be considered in case of acute renal failure in children, mostly when other common causes have been excluded, and there is a history of drug exposure.
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Bases de datos:
MEDLINE
Asunto principal:
Antibacterianos
/
Nefritis Intersticial
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Urol Int
Año:
2006
Tipo del documento:
Article
País de afiliación:
Grecia