Cyclobutane derivatives as potent NK1 selective antagonists.

Wrobleski, Michelle Laci; Reichard, Gregory A; Paliwal, Sunil; Shah, Sapna; Tsui, Hon-Chung; Duffy, Ruth A; Lachowicz, Jean E; Morgan, Cynthia A; Varty, Geoffrey B; Shih, Neng-Yang

Wrobleski, Michelle Laci; Reichard, Gregory A; Paliwal, Sunil; Shah, Sapna; Tsui, Hon-Chung; Duffy, Ruth A; Lachowicz, Jean E; Morgan, Cynthia A; Varty, Geoffrey B; Shih, Neng-Yang.

Afiliación

Wrobleski ML; Chemical Research Department, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.

Bioorg Med Chem Lett ; 16(14): 3859-63, 2006 Jul 15.

Article en En | MEDLINE | ID: mdl-16682196

ABSTRACT

ABSTRACT

A series of novel cyclobutane derivatives as potent and selective NK1 receptor antagonists is described. Several compounds in this series exhibited high in vitro binding affinity (Ki oral administration. Syntheses of these compounds are also described herein.

Asunto(s)

Ciclobutanos/farmacología; Antagonistas del Receptor de Neuroquinina-1; Antagonistas de la Serotonina/química; Antagonistas de la Serotonina/farmacología; Animales; Sitios de Unión; Ciclobutanos/química; Estereoisomerismo; Relación Estructura-Actividad

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Bases de datos: MEDLINE Asunto principal: Antagonistas de la Serotonina / Ciclobutanos / Antagonistas del Receptor de Neuroquinina-1 Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos

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