Controlled release of phosphorothioates by protein-based polymers.
Drug Deliv
; 13(4): 253-9, 2006.
Article
en En
| MEDLINE
| ID: mdl-16766466
ABSTRACT
Protein-based polymers are water soluble at lower temperatures but undergo a phase transition with increasing temperature. The polymers' hydrophobicity controls the transition temperature and the free energy of its charged groups through an apolar-polar repulsive free energy of hydration, which drives the binding of charged drugs. Binding and release of phosphorothioates were obtained with polymers containing 1 lysine alone or coupled with 2 to 5 phenylalanines per 30 residues. Release rates from 4 to 64 nmol/ cm2/day were maintained constant for 8 to 2 weeks/mm, respectively. We demonstrated the ability of protein-based polymers to deliver nucleic acid based therapeutics with high programmability.
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Bases de datos:
MEDLINE
Asunto principal:
Fosfatos
/
Polímeros
/
Proteínas Recombinantes
/
Oligonucleótidos Antisentido
Idioma:
En
Revista:
Drug Deliv
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos