Regulation of peripheral B cell maturation.
Cell Immunol
; 239(2): 92-102, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16797504
ABSTRACT
Although it is clear that the final phases of B cell maturation occur after newly formed B cells exit the bone marrow, the mechanisms underpinning the maturation, selection, and long-term survival of immature peripheral B cells remain poorly understood. Here, we review recent advances in our understanding of how B cell receptor (BCR)-mediated signaling events integrate with additional environmental cues to promote the selection and differentiation of immature B cells into functionally distinct subpopulations of mature B cells. We pay particular attention to the role of the Baff cytokine family and the Notch receptor-ligand family and their unique roles in promoting B cell survival and differentiation into follicular and marginal zone B cells.
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Bases de datos:
MEDLINE
Asunto principal:
Diferenciación Celular
/
Subgrupos de Linfocitos B
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Immunol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos