West Nile virus immunoglobulin A (WNV IgA) detection in cerebrospinal fluid in relation to WNV IgG and IgM reactivity.
J Clin Virol
; 37(3): 174-8, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-16939715
ABSTRACT
BACKGROUND:
Diagnostic criteria for neurologic involvement in WNV infection include WNV IgM detection in CSF; however, WNV IgM can persist in CSF >6 months. CSF IgA characterizes other flavivirus infections, but WNV IgA in CSF has not been evaluated. WNV IgM in CSF correlates with IgM in serum but the presence of WNV IgA in CSF compared to serum is unknown.OBJECTIVES:
Evaluate WNV IgA detection in CSF as a marker of WNV neuroinvasive infection, initially with samples pre-selected based on WNV IgG and IgM reactivity and subsequently with all available CSF samples submitted for WNV antibody testing over an entire WNV season. STUDYDESIGN:
Selected CSF samples and CSF/serum pairs previously tested for WNV IgG and IgM were assayed for WNV IgA. Subsequently, all available CSF samples tested for WNV antibodies during the 2005 season were tested for WNV IgA, including those where paired sera were available and tested for IgA, IgG and IgM.RESULTS:
For most samples, including paired CSF and serum, the IgA result qualitatively agreed with the IgM result, regardless of the IgG result.CONCLUSION:
IgA detection is equivalent to IgM detection as a marker of WNV infection in CSF.
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Bases de datos:
MEDLINE
Asunto principal:
Fiebre del Nilo Occidental
/
Virus del Nilo Occidental
/
Inmunoglobulina A
/
Inmunoglobulina G
/
Inmunoglobulina M
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
J Clin Virol
Asunto de la revista:
VIROLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos