Effect of rebamipide on the colonic barrier in interleukin-10-deficient mice.
Dig Dis Sci
; 52(1): 84-92, 2007 Jan.
Article
en En
| MEDLINE
| ID: mdl-17186389
ABSTRACT
Our aim was to study the effect of a mucosal protective agent, rebamipide, on the colonic barrier and the immune response in colitis-prone interleukin-10-deficient (IL-10-/-) C57BL/6 mice infected with Helicobacter hepaticus. After sacrifice, in all mice, control, or previously infected with H. hepaticus, or previously infected and treated with rebamipide enema, a histological examination of colonic samples was performed, intestinal permeability was studied in Ussing chamber, and mesenteric lymph node proliferation and cytokine secretion were measured. Mice treated with rebamipide presented a reinforcement of the distal colonic epithelial barrier, an increase of mesenteric lymph node cells proliferation, and of IFNgamma and IL-12 secretion. These results indicate that in IL-10-/- mice with mild colitis, rectally administered rebamipide reinforces the distal colonic barrier and has a slight Th1 immuno-stimulatory effect on mesenteric lymph node cells. These properties could be helpful in the management of some inflammatory bowel diseases.
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Bases de datos:
MEDLINE
Asunto principal:
Infecciones por Helicobacter
/
Colon
/
Quinolonas
/
Alanina
/
Mucosa Intestinal
/
Antiulcerosos
Tipo de estudio:
Evaluation_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia