A case of fibrous hamartoma of infancy: an immunohistochemical study.

ABSTRACT

To clarify the histogenesis and immunohistochemical nature of fibrous hamartoma of infancy, we have studied a typical case of this disease using an immunohistochemical technique with a large panel of antibodies. It was found that immature-appearing stellate and spindle-shaped cells were mesenchymal in nature, but it was not ascertained whether those cells were differentiated into various specialized connective tissues corresponding with embryonic stages of connective tissue differentiation. These results reveal the immunohistochemical nature of tissue components of fibrous hamartoma but poorly support the previously described concept that fibrous hamartoma of infancy is a hamartomatous disease.