[Pathomorphosis of acute leukemia]. / O patomorfoze ostrykh leikozov.

ABSTRACT

Macro- and microscopic examinations of the viscera and hemopoietic organs of 405 dead patients who had suffered from various forms of acute leukemia were performed as well as microscopic investigations of 560 punch biopsies obtained from 372 patients at different stages of the disease. Pathomorphological findings on acute leukemias are presented, changes in the disease in the course of cytostatic antileukemia treatment are observed. Morphological signs of therapeutic pathomorphosis of acute leukemia involve reduction or eradication of leukemic growths in the viscera and hemopoietic organs; hemopoietic hypo- and aplasia; dystrophic and necrobiotic alterations in the organs; topographic changes of leukemic proliferates (extramedullary localization of the process); augmentation of infectious and inflammatory complications; other causes of death.