Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88.
Nat Biotechnol
; 25(2): 221-31, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17259976
ABSTRACT
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis.
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas de Plantas
/
Aspergillus niger
/
Cromosomas Fúngicos
/
Mapeo Cromosómico
/
Genoma Fúngico
/
Análisis de Secuencia de ADN
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Nat Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Países Bajos