Applications of LC/MS in structure identifications of small molecules and proteins in drug discovery.
J Mass Spectrom
; 42(3): 279-87, 2007 Mar.
Article
en En
| MEDLINE
| ID: mdl-17295416
ABSTRACT
With advancements in ionization methods and instrumentation, liquid chromatography/mass spectrometry (LC/MS) has become a powerful technology for the characterization of small molecules and proteins. This article will illustrate the role of LC/MS analysis in drug discovery process. Examples will be given on high-throughput analysis, structural analysis of trace level impurities in drug substances, identification of metabolites, and characterization of therapeutic protein products for process improvement. Some unique MS techniques will also be discussed to demonstrate their effectiveness in facilitating structural identifications.
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Bases de datos:
MEDLINE
Asunto principal:
Espectrometría de Masas
/
Biopolímeros
/
Mapeo Peptídico
/
Diseño de Fármacos
/
Proteínas
/
Cromatografía Liquida
/
Análisis de Secuencia de Proteína
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
J Mass Spectrom
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos