Drug-induced liver injury at an Asian center: a prospective study.
Liver Int
; 27(4): 465-74, 2007 May.
Article
en En
| MEDLINE
| ID: mdl-17403186
ABSTRACT
BACKGROUND/AIMS:
The aetiology of drug-induced liver injuries (DILI) in Asia is different from that in the West, as anecdotal studies have shown that traditional complementary and alternative medicines (CAM) accounted for a major proportion of offending drugs in DILI in Asia. We aimed to study DILI in Asia prospectively, and to test whether DILI caused by traditional CAM was related to adulterants.METHODS:
A collaborative group consisting of a tertiary-hospital hepatology department, a pharmaceutical laboratory, and a pharmacovigilance unit was formed to study patients with DILI at a tertiary hospital over a 26-month period prospectively. Traditional medicines that were implicated were tested for the presence of adulterants.RESULTS:
Thirty-one patients with DILI were enrolled age 51+/-3 (18-79) years, 17 (55%) male. Twenty-three (74%) had hepatocellular, six (19%) had cholestatic, and two (7%) had a mixed pattern of injury. Chinese traditional CAM was the most common medication type implicated, accounting for 17 (55%) patients, followed by Malay CAM in five (16%). Thirty-one traditional medicines from 17 patients were available for chemical analysis. Adulterants were found in nine (29%) of them.CONCLUSIONS:
DILI in Asia has a different aetiology as compared with the West, and could be related to presence of adulterants in traditional CAM.
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Bases de datos:
MEDLINE
Asunto principal:
Terapias Complementarias
/
Contaminación de Medicamentos
/
Enfermedad Hepática Inducida por Sustancias y Drogas
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Liver Int
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Singapur