Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors.
Bioorg Med Chem Lett
; 17(16): 4683-8, 2007 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-17555959
ABSTRACT
This paper describes the synthesis of orally available potent fXa inhibitors 2 and 3 by modification of the piperazine part of lead compound 1. Carbonyl derivative 3 showed potent fXa activity but not sulfonyl derivative 2. Among the compounds synthesized, cyclohexane derivatives 3g and 3h and cycloheptane derivative 3j had potent anticoagulant activity as well as anti-fXa activity. Synthetic study of the optical isomers of 3g demonstrated that (-)-3g had more potent activity.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Cicloparafinas
/
Inhibidores del Factor Xa
/
Anticoagulantes
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Japón