A high-resolution atlas of nucleosome occupancy in yeast.
Nat Genet
; 39(10): 1235-44, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-17873876
ABSTRACT
We present the first complete high-resolution map of nucleosome occupancy across the whole Saccharomyces cerevisiae genome, identifying over 70,000 positioned nucleosomes occupying 81% of the genome. On a genome-wide scale, the persistent nucleosome-depleted region identified previously in a subset of genes demarcates the transcription start site. Both nucleosome occupancy signatures and overall occupancy correlate with transcript abundance and transcription rate. In addition, functionally related genes can be clustered on the basis of the nucleosome occupancy patterns observed at their promoters. A quantitative model of nucleosome occupancy indicates that DNA structural features may account for much of the global nucleosome occupancy.
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Bases de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
/
Nucleosomas
/
Genoma Fúngico
Idioma:
En
Revista:
Nat Genet
Asunto de la revista:
GENETICA MEDICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos