Sensor complexes regulating two-component signal transduction.
Curr Opin Struct Biol
; 17(6): 706-15, 2007 Dec.
Article
en En
| MEDLINE
| ID: mdl-17913492
ABSTRACT
Two-component signal transduction systems consisting of a sensor histidine kinase and a response regulator/transcription factor interpret a multitude of environmental and cellular signals and coordinate the expression of a wide array of genes in bacteria. Signal recognition by sensor histidine kinases is the province of a sensor complex consisting of several protein domains that together serve to augment or attenuate the activity of the histidine kinase and thereby of gene expression. Recent investigations have shown the diverse strategies bacteria use to assemble protein domains into the sensor complexes to accomplish signaling. Structural studies of such domains are leading to an understanding of the mechanisms by which sensor complexes recognize signals and regulate kinase activity.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Transducción de Señal
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Curr Opin Struct Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos