Colitis associated with Clostridium difficile in specific-pathogen-free C3H-scid mice.
J Vet Med Sci
; 69(9): 973-5, 2007 Sep.
Article
en En
| MEDLINE
| ID: mdl-17917386
ABSTRACT
Soft feces and a decreased delivery rate were observed in a specific-pathogen-free (SPF) C3H-scid mouse breeding colony. Grossly, the ceca were shrunken and edematous in the affected mice. Histopathologically, severe edema in the cecal submucosa as well as infiltration of inflammatory cells in the lamina propria and submucosa of the ceca and colon were observed. No pathogenic microorganisms were detected by the routine microbiological tests. By anaerobic bacterial-examination, Clostridium (C.) difficile with toxin A was isolated from the cecal contents of the affected mice. The mice were diagnosed with C. difficile-associated colitis. This case appears to be the first report of natural infection with C. difficile in SPF mice with clinical signs.
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedades de los Roedores
/
Enterocolitis Seudomembranosa
/
Clostridioides difficile
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Vet Med Sci
Asunto de la revista:
MEDICINA VETERINARIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Japón