[The pathogenesis of Parkinson's disease: a hint from insights of familial Parkinson's disease].
Rinsho Shinkeigaku
; 47(11): 774-8, 2007 Nov.
Article
en Ja
| MEDLINE
| ID: mdl-18210796
ABSTRACT
Parkinson's disease (PD) is a progressive movement disorder characterized by resting tremor, rigidity, akinesia, and postural instability. In addition, PD is characterized by the appearance of Lewy bodies in the remaining neurons. The exact etiology for this disease is still unknown. However, genetic-environmental interaction could contribute the pathomechanisms of PD. Indeed, totally seven causative genes responsible for familial PD have been identified. Since discovery of familial PD (FPD), genetic PD models have been developed. Thus, we think that the research field of FPD provides us a good hint for the pathogenesis of nigral degeneration in not only familial but also sporadic form of PD.
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
Ja
Revista:
Rinsho Shinkeigaku
Año:
2007
Tipo del documento:
Article