GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis.
Biochem Biophys Res Commun
; 367(4): 793-8, 2008 Mar 21.
Article
en En
| MEDLINE
| ID: mdl-18211828
ABSTRACT
To clarify the cytoprotective effect of glucagon-like peptide-1 receptor (GLP-1R) signaling in conditions of glucose toxicity in vivo, we performed murine isogenic islet transplantation with and without exendin-4 treatment. When a suboptimal number of islets (150) were transplanted into streptozotocin-induced diabetic mice, exendin-4 treatment contributed to the restoration of normoglycemia. When 50 islets expressing enhanced green fluorescent protein (EGFP) were transplanted, exendin-4 treatment reversed loss of both the number and mass of islet grafts one and 3 days after transplantation. TUNEL staining revealed that exendin-4 treatment reduced the number of apoptotic beta cells during the early posttransplant phase, indicating that GLP-1R signaling exerts its cytoprotective effect on pancreatic beta cells by inhibiting their apoptosis. This beneficial effect might be used both to ameliorate type 2 diabetes and to improve engraftment rates in clinical islet transplantation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Péptidos
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Ponzoñas
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Transducción de Señal
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Trasplante de Islotes Pancreáticos
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Islotes Pancreáticos
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Apoptosis
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Diabetes Mellitus Experimental
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Péptido 1 Similar al Glucagón
Límite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón