Muscling through the microRNA world.
Exp Biol Med (Maywood)
; 233(2): 131-8, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18222968
ABSTRACT
microRNAs (miRNAs) are a class of highly conserved small non-coding RNAs that negatively regulate gene expression post-transcriptionally. The emerging field of miRNA biology has begun to unravel roles for these regulatory molecules in a range of biological functions, including cardiac and skeletal muscle development, as well as in muscle-related disease processes. In this paper, we review the role of miRNAs in muscle biology. Recent genetic studies have demonstrated that miRNAs are required for both proper muscle development and function, with crucial roles for miRNAs being identified in regulating muscle cell proliferation and differentiation. Furthermore, dysregulated expression of miRNAs has been correlated to certain muscle-related diseases, including cardiac hypertrophy, cardiac arrhythmias, and muscular dystrophy.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
MicroARNs
/
Músculos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Biol Med (Maywood)
Asunto de la revista:
BIOLOGIA
/
FISIOLOGIA
/
MEDICINA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos