Inhibition of Helicobacter pylori infection in humans by Lactobacillus reuteri ATCC 55730 and effect on eradication therapy: a pilot study.
Helicobacter
; 13(2): 127-34, 2008 Apr.
Article
en En
| MEDLINE
| ID: mdl-18321302
ABSTRACT
BACKGROUND:
Several studies report an inhibitory effect of probiotics on Helicobacter pylori.AIM:
To test whether Lactobacillus reuteri ATCC 55730 reduces H. pylori intragastric load in vivo, decreases dyspeptic symptoms, and affects eradication rates after conventional treatment. MATERIALS ANDMETHODS:
In a double-blind placebo-controlled study, 40 H. pylori-positive subjects were given L. reuteri once a day for 4 weeks or placebo. All underwent upper endoscopy, (13)C-urea breath test, and H. pylori stool antigen determination at entry and (13)C-urea breath test and H. pylori stool antigen (used as both qualitative and semiquantitative markers) after 4 weeks of treatment. Sequential treatment was administered subsequently to all.RESULTS:
In vivo, L. reuteri reduces H. pylori load as semiquantitatively assessed by both (13)C-urea breath test delta-value and H. pylori stool antigen quantification after 4 weeks of treatment (p < .05). No change was shown in patients receiving placebo. L. reuteri administration was followed by a significant decrease in the Gastrointestinal Symptom Rating Scale as compared to pretreatment value (p < .05) that was not present in those receiving placebo (p = not significant). No difference in eradication rates was observed.CONCLUSIONS:
L. reuteri effectively suppresses H. pylori infection in humans and decreases the occurrence of dyspeptic symptoms. Nevertheless, it does not seem to affect antibiotic therapy outcome.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proyectos Piloto
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Helicobacter pylori
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Infecciones por Helicobacter
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Probióticos
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Limosilactobacillus reuteri
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Antígenos Bacterianos
Tipo de estudio:
Clinical_trials
/
Qualitative_research
Límite:
Humans
Idioma:
En
Revista:
Helicobacter
Asunto de la revista:
BACTERIOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Italia