Structure and semisynthesis of platensimide A, produced by Streptomyces platensis.
Org Lett
; 10(9): 1699-702, 2008 May 01.
Article
en En
| MEDLINE
| ID: mdl-18393511
ABSTRACT
Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, respectively. Continued search for the natural congeners of these compounds led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide derivative. Isolation, structure, semisynthesis, and activity of these compounds are described.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Compuestos Policíclicos
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Streptomyces
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Hidrocarburos Aromáticos con Puentes
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Adamantano
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Aminobenzoatos
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Aminobutiratos
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Aminofenoles
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Anilidas
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Antibacterianos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos