Effect of cyclosporin A on B cell maturation and differentiation.
Drugs Exp Clin Res
; 17(10-11): 493-500, 1991.
Article
en En
| MEDLINE
| ID: mdl-1841038
ABSTRACT
The activation and differentiation of resting B cells into Ig secreting cells are regulated by T cells, macrophages and their secreted factors. The present study evaluated the effect of cyclosporin A (CsA) on this process. Peripheral blood lymphomonocytes (PBMC) drawn from healthy donors were stimulated with protein A (PA) or with lipopolysaccharides plus pokeweed (LPS+PWM) in either the presence or the absence of CsA. Phenotypic B cell changes and immunoglobulin production was then analyzed. The data revealed that CsA decreased the expression of B cell surface receptors of the activation phase, and enhanced the resting phase receptors. Different effects of CsA were found on B cell differentiation, depending on its induction by PA or LPS+PWM. In the first system, CsA decreased the expression of differentiation phase receptors and the secretion of free Ig. In cultures stimulated with LPS+PWM, CsA increased the differentiated phase receptors and Ig secretion. Thus, CsA seemed to act as a blocking agent of the activation phase and as a modulator of the differentiation phase and of IgG secretion, depending upon the antigen used for stimulation.
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Bases de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Ciclosporina
Límite:
Humans
Idioma:
En
Revista:
Drugs Exp Clin Res
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia