Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice.
Ophthalmic Res
; 40(3-4): 115-9, 2008.
Article
en En
| MEDLINE
| ID: mdl-18421223
ABSTRACT
Drusen, the white yellowish deposits that can be seen in funduscopy, are a hallmark of age-related macular degeneration. Histologically, drusen are believed to be dome-shaped or more confluent lipid accumulations between the retinal pigment epithelium and the choriocapillaries. Recent advances in mouse funduscopy have revealed the presence of drusen-like structures in chemokine knockout animals in the absence of sizeable dome-shaped material below the retinal pigment epithelium. We show that aged CX3CR1-/- mice present with drusen-like appearance in funduscopy that is associated with a progressive age-related microglial cell accumulation in the subretinal space. We demonstrate that the anatomical equivalent of the drusen-like appearance in these mice are lipid-bloated subretinal microglial cells rather than subretinal pigment epithelium deposits [Combadière C, et al J Clin Invest 2007;1172920-2928].
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Epitelio Pigmentado Ocular
/
Drusas Retinianas
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Microglía
/
Receptores de Quimiocina
Límite:
Animals
Idioma:
En
Revista:
Ophthalmic Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
Francia