Models of nociception: hot-plate, tail-flick, and formalin tests in rodents.
Curr Protoc Neurosci
; Chapter 8: Unit 8.9, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-18428666
ABSTRACT
Experimental models of pain include tests of response thesholds to high intensity stimuli (acute pain tests) and changes in spontaneous or evoked behavioral responses in animals with peripheral injury or inflammation (persistent pain models). Acute thermal pain is modeled by the hot-plate and tail-flick test, while persistent pain can be modeled by the formalin test. This unit presents protocols for all three of these tests, including preparation of animals (rats or mice), administration of a compound being tested for its analgesic properties and data collection.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Dolor
/
Dimensión del Dolor
/
Nociceptores
/
Umbral del Dolor
Límite:
Animals
Idioma:
En
Revista:
Curr Protoc Neurosci
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos