Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesis.
Breast Cancer Res Treat
; 114(3): 599-605, 2009 Apr.
Article
en En
| MEDLINE
| ID: mdl-18465220
ABSTRACT
Several independent studies have presented evidence for the involvement of human papillomaviruses (HPV) in the aetiology of human breast cancer, while others have reported the opposite findings. Here, we have analysed by a high sensitive multiplex PCR-based method the prevalence of alpha mucosal and beta cutaneous HPV DNA in 90 ductal lavages, colostrum and milk. Ten of the 70 DLs analyzed (14%) contained a single or multiple beta HPV types, while DNA from mucosal high-risk HPV types was detected in only one sample (1/70). A strong reduction of HPV positivity in DL fluids was observed in 45 specimens collected after removal of the superficial layers of the nipple epidermis. All DLs were negative for the mucosal low-risk HPV types 6 and 11. Finally, HPV positivity was low in colostrum and milk. Our data show that DNA of alpha mucosa and beta cutaneous HPV types are rarely present in the breast fluids and suggest that a direct role of HPV in breast carcinogenesis is unlikely.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Líquidos Corporales
/
Neoplasias de la Mama
/
Calostro
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Infecciones por Papillomavirus
/
Leche Humana
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
/
Middle aged
Idioma:
En
Revista:
Breast Cancer Res Treat
Año:
2009
Tipo del documento:
Article
País de afiliación:
Italia