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uPA and PAI-1 in rectal cancer--relationship to radiotherapy and clinical outcome.
Angenete, Eva; Langenskiöld, Marcus; Palmgren, Ingrid; Falk, Peter; Oresland, Tom; Ivarsson, Marie-Louise.
Afiliación
  • Angenete E; Department of Surgery, Sahlgrenska University Hospital/Ostra, Göteborg University, Gothenburg, Sweden. eva.angenete@vgregion.se
J Surg Res ; 153(1): 46-53, 2009 May 01.
Article en En | MEDLINE | ID: mdl-18533186
ABSTRACT

BACKGROUND:

It is well known that the fibrinolytic system is of importance in inflammation, wound healing, and fibrosis development. However, it is also important in the process of tumor invasion and metastasis. We have investigated protein levels of urokinase plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in rectal cancer and effects of radiotherapy, links to clinical outcome, and potential use as prognostic factors. MATERIALS AND

METHODS:

Ninety-one patients with rectal cancer were studied. Blood samples and biopsies were taken during surgery and assayed with enzyme-linked immunosorbent assay for uPA and PAI-1, and patients were followed prospectively (0-96 mo).

RESULTS:

Higher levels of uPA (P < 0.0001) and PAI-1 (P < 0.0001) were found in tumor compared with mucosa. Mucosa exposed to radiotherapy had higher levels of uPA (P < 0.0001) and of PAI-1 (P < 0.0001). Irradiated tumor tissue had higher levels of PAI-1 (P < 0.001). PAI-1 in tumor was correlated with T stage (P < 0.001) and N stage (P < 0.01). PAI-1 in plasma was higher in patients with synchronous distant metastases (P < 0.001). Cox regression was used to identify high levels of PAI-1 in tumor as an independent factor related to short disease-free survival (P < 0.01) and the ratio of uPA/PAI-1 to development of metastases (P < 0.01).

CONCLUSIONS:

There is a relationship between PAI-1 in plasma and rectal cancer metastases. PAI-1 in tumor tissue is correlated to histopathological data and to outcome of rectal cancer. If these findings can be confirmed in larger trials, there will be a possibility to use PAI-1 as a prognostic factor.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias del Recto / Activador de Plasminógeno de Tipo Uroquinasa / Inhibidor 1 de Activador Plasminogénico Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Surg Res Año: 2009 Tipo del documento: Article País de afiliación: Suecia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias del Recto / Activador de Plasminógeno de Tipo Uroquinasa / Inhibidor 1 de Activador Plasminogénico Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Surg Res Año: 2009 Tipo del documento: Article País de afiliación: Suecia