Tomoeones A-H, cytotoxic phloroglucinol derivatives from Hypericum ascyron.
Phytochemistry
; 69(11): 2225-30, 2008 Aug.
Article
en En
| MEDLINE
| ID: mdl-18556029
ABSTRACT
Phloroglucinol derivatives tomoeones A-H (1-8) and three known compounds were isolated from leaves of Hypericum ascyron. Their structures were established based on spectroscopic analyses. They are all acylphloroglucinol derivatives possessing a spiro skeleton with geminal isoprenyl groups and a monoterpene moiety, and they are stereoisomers to each other at C-4 and C-13. They appear to be a class of phloroglucinol derivatives. Cytotoxicities of the isolated phloroglucinol derivatives against human tumor cell lines, including multidrug-resistant (MDR) cancer cell lines, were evaluated. Tomoeone F (6) demonstrated significant cytotoxicity against KB cells with an IC50 value of 6.2 microM. Compound 6 was also cytotoxic against MDR cancer cell lines (KB-C2 and K562/Adr), which was more potent than doxorubicin.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Floroglucinol
/
Hypericum
Límite:
Humans
Idioma:
En
Revista:
Phytochemistry
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón