Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors.
Bioorg Med Chem Lett
; 18(14): 3895-8, 2008 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-18590959
ABSTRACT
The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA(4)-h inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the diphenyl ether moiety and diamine spacer is discussed. The resulting compounds such as 3l have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Química Farmacéutica
/
Diaminas
/
Inhibidores Enzimáticos
/
Epóxido Hidrolasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos