Synthesis of substituted N-benzyl pyridones via an O- to N-alkyl migration.
J Org Chem
; 73(16): 6425-8, 2008 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-18610979
ABSTRACT
A new LiI-promoted O- to N-alkyl migration has been developed for the conversion of O-alkylated 2-hydroxy pyridines, quinolines, and pyrimidines to the corresponding N-alkylated heterocycles in good to excellent yields (57-99%). This method serves as an efficient means for the preparation of N-benzyl pyridones, quinolones, and pyrimidones.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piridonas
/
Compuestos de Bencilo
Idioma:
En
Revista:
J Org Chem
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos