Tetany in kala azar patients treated with paromomycin.
Indian J Med Res
; 127(5): 489-93, 2008 May.
Article
en En
| MEDLINE
| ID: mdl-18653914
ABSTRACT
Paromomycin, an aminoglycoside, is known to cause several side effects like nephrotoxicity and ototoxicity like other aminoglycosides but tetany has not been reported. Three cases of tetany were detected in the patients of kala-azar treated with paromomycin. They were promptly treated with intravenous 10 per cent calcium gluconate and tetany was relieved immediately and treatment with paromomycin continued with oral calcium supplement. After completion of 21 days treatment with paromomycin patients' splenic aspirates were free of parasites. Paromomycin may cause temporary tubular damage leading to calcium wasting in urine and hypocalcaemia resulting in tetany. Prompt detection of symptoms and intravenous calcium gluconate treatment promptly reverse the situation.
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Bases de datos:
MEDLINE
Asunto principal:
Tetania
/
Paromomicina
/
Leishmaniasis Visceral
/
Antibacterianos
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Indian J Med Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
India