Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D.
Nat Immunol
; 9(9): 1065-73, 2008 Sep.
Article
en En
| MEDLINE
| ID: mdl-18677316
ABSTRACT
MICA and MICB are stress-induced ligands recognized by the activating receptor NKG2D. A microRNA encoded by human cytomegalovirus downregulates MICB expression by targeting a specific site in the MICB 3' untranslated region. As this site is conserved among different MICB alleles and a similar site exists in the MICA 3' untranslated region, we speculated that these sites are targeted by cellular microRNAs. Here we identified microRNAs that bound to these MICA and MICB 3' untranslated region sequences and obtained data suggesting that these microRNAs maintain expression of MICA and MICB protein under a certain threshold and facilitate acute upregulation of MICA and MICB during cellular stress. These microRNAs were overexpressed in various tumors and we demonstrate here that they aided tumor avoidance of immune recognition.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
/
Receptores Inmunológicos
/
Antígenos de Histocompatibilidad Clase I
/
MicroARNs
Límite:
Humans
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Israel