[The contribution for the diagnosis of the tumor-like polypoid lesions of the gallbladder by SELDI-TOF-MS].
Zhonghua Wai Ke Za Zhi
; 46(7): 525-7, 2008 Apr 01.
Article
en Zh
| MEDLINE
| ID: mdl-18785564
ABSTRACT
OBJECTIVE:
To detect the serum specific proteins in tumor-like polypoid lesions of the gallbladder patients and establish diagnostic model.METHODS:
Surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) technique and WCX Magnetic Beads were used to detect the serum proteomic patterns of 23 patients with tumor-like PLG, 21 patients with non tumor-like PLG and 26 normal persons. Biomarker Wizard and Biomarker Patterns Software were used in combination to analyze the data.RESULTS:
Preliminary screening out 22 representative specific proteins for the diagnosis of the tumor-like PLG. Analysis system under the conditions set selected 3 specific proteins to establish diagnostic model for the tumor-like PLG. The sensitivity and specificity of the model for the diagnosis of the tumor-like PLG were 100% and 89.4%, respectively.CONCLUSION:
SELDI-TOF-MS technique can select specific protein of the tumor-like PLG, and establish diagnostic model of the tumor-like PLG.
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Bases de datos:
MEDLINE
Asunto principal:
Pólipos
/
Proteínas Sanguíneas
/
Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción
/
Neoplasias de la Vesícula Biliar
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Wai Ke Za Zhi
Año:
2008
Tipo del documento:
Article
País de afiliación:
China