The Y chromosome and male infertility.
Curr Opin Urol
; 18(6): 628-32, 2008 Nov.
Article
en En
| MEDLINE
| ID: mdl-18832950
ABSTRACT
PURPOSE OF REVIEW Therapies for the treatment of severe male factor infertility have advanced well beyond our knowledge of the conditions we are treating. An intact Y chromosome is necessary for optimal spermatogenesis. It is imperative for the clinician to understand the molecular basis and clinical implications of anomalies that might afflict the Y chromosome. RECENT FINDINGS:
The molecular geography of the Y chromosome has recently been described, allowing correlations to be made to various clinical states of severe spermatogenic compromise. Microdeletions of parts of the Y chromosome are found in a small number of men with spermatogenic failure involving, predominantly, three regions termed AZFa, AZFb, and AZFc.SUMMARY:
It is necessary that a Y chromosomal microdeletion assay be carried out prior to any intervention using ejaculated sperm or prior to any surgical procedure to try to find spermatozoa in an azoospermic man.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Espermatogénesis
/
Deleción Cromosómica
/
Cromosomas Humanos Y
/
Infertilidad Masculina
Tipo de estudio:
Prognostic_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Curr Opin Urol
Asunto de la revista:
UROLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos