Management and successful desensitization in methotrexate-induced anaphylaxis.
Pediatr Blood Cancer
; 52(2): 295-7, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-18855892
ABSTRACT
Anaphylactic/anaphylactoid reactions to methotrexate are rare. In patients with methotrexate-induced anaphylaxis, discontinuation of treatment may increase the risk of death due to cancer progression. In such patients, desensitization may enable the patient to continue treatment with methotrexate. We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate. Skin tests with methotrexate were not performed because their diagnostic value is controversial. Desensitization with methotrexate was successful and allowed the patient to complete 12 additional courses of chemotherapy. Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Metotrexato
/
Desensibilización Inmunológica
/
Hipersensibilidad a las Drogas
/
Anafilaxia
Límite:
Child
/
Humans
Idioma:
En
Revista:
Pediatr Blood Cancer
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Francia