Structure of a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 64(Pt 10): 875-9, 2008 Oct 01.
Article
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| MEDLINE
| ID: mdl-18931427
ABSTRACT
The X-ray crystal structure of the 6-pyruvoyltetrahydropterin synthase (PTPS) homolog from Streptomyces coelicolor, SCO 6650, was solved at 1.5 A resolution. SCO 6650 forms a hexameric T-fold that closely resembles other PTPS proteins. The biological activity of SCO 6650 is unknown, but it lacks both a required active-site zinc metal ion and the essential catalytic triad and does not catalyze the PTPS reaction. However, SCO 6650 maintains active-site residues consistent with binding a pterin-like substrate.
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1
Bases de datos:
MEDLINE
Asunto principal:
Liasas de Fósforo-Oxígeno
/
Streptomyces coelicolor
Idioma:
En
Revista:
Acta Crystallogr Sect F Struct Biol Cryst Commun
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos