Comparative cognitive effects of levetiracetam and topiramate in intractable epilepsy.
Psychiatry Clin Neurosci
; 62(5): 548-53, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18950374
ABSTRACT
AIM:
Anti-epileptic drugs (AED) may cause cognitive impairment. Because intractable epilepsy (IE) represents a distinct group, the purpose of the present study was to study the comparative cognitive effects of the two efficacious AED, levetiracetam (LEV) and topiramate (TPM), on IE.METHODS:
This was a non-randomized, blinded cognitive assessment and parallel design. The cognitive effects of LEV and TPM on 79 demographically comparable patients with IE were assessed at baseline (T1) and after 1 year of treatment (T2) using the Cognitive Abilities Screening Instrument.RESULTS:
Forty patients took TPM and 39 took LEV. At T1, seizure frequency, number of AED, and epilepsy duration were not significantly different. There were no significant differences in cognition between the two groups at T1 or T2. T2 orientation scores were lower than T1 scores in the TPM group (P < 0.05). In the TPM subgroup with T1 cognitive abnormalities, T2 scores for recent memory improved (P < 0.05).CONCLUSION:
For patients with IE, LEV might preserve cognition, TPM's effects for patients with baseline cognitive abnormalities are worth observation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piracetam
/
Epilepsia Parcial Compleja
/
Epilepsias Parciales
/
Epilepsia Tónico-Clónica
/
Trastornos del Conocimiento
/
Fructosa
/
Anticonvulsivantes
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Psychiatry Clin Neurosci
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Taiwán