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[Serum inhibin B in polycystic ovary syndrome as a potential marker of ovarian dysfunction].
Srp Arh Celok Lek ; 136(7-8): 379-83, 2008.
Article en Sr | MEDLINE | ID: mdl-18959173
ABSTRACT

INTRODUCTION:

Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulation, infertility and hyperandrogenism, and the prevalence of this condition in women of reproductive is 5-10%. The growth of early ovarian antral follicles is arrested and dominant follicle selection is disturbed in this syndrome.

OBJECTIVE:

The aim of this study is to investigate whether inhibin B serum concentrations represent the extent of ovarian abnormalities in patients with PCOS.

METHOD:

Inhibin B serum concentrations on the third day of spontaneous menstrual cycle and other endocrine characteristics were compared between 20 patients with PCOS and 19 healthy women in the control group.

RESULTS:

Inhibin B concentrations were not significantly different between women with PCOS and women in the control group. In patients with PCOS there was statistically significant correlation between serum inhibin B and LH (r = 0.514; p = 0.021).There were no positive correlations between inhibin B and others endocrine parameters in patients with PCOS (FSH, E2,T, androstenedione).

CONCLUSION:

Inhibin B serum concentrations on the third day of spontaneous menstrual cycle in women with PCOS are not different from the concentrations in healthy women. Serum Inhibin B levels in patients with PCOS are only slightly correlated with the endocrine markers of the disease so it could not represent the magnitude of ovarian dysfunction in this syndrome.
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Bases de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Inhibinas Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: Sr Revista: Srp Arh Celok Lek Año: 2008 Tipo del documento: Article
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Bases de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Inhibinas Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: Sr Revista: Srp Arh Celok Lek Año: 2008 Tipo del documento: Article