New water-soluble azido- and derived tetrazolato-platinum(II) complexes with PTA. Easy metal-mediated synthesis and isolation of 5-substituted tetrazoles.
Dalton Trans
; (46): 6546-55, 2008 Dec 14.
Article
en En
| MEDLINE
| ID: mdl-19030616
ABSTRACT
The water-soluble four- and five-coordinate diazido-platinum(II) complexes cis-[Pt(N3)2(PTA)2] (1) (PTA = 1,3,5-triaza-7-phosphaadamantane), cis-[Pt(N3)2(Me-PTA)2]I2 (2) (Me-PTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation) and [Pt(N3)2(PTA)3] (3) were obtained by reactions of cis-[Pt(N3)2(PPh3)2] with PTA or [Me-PTA]I in dichloromethane. [2 + 3] cycloadditions of with organonitriles NCR gave the bis(tetrazolato) complexes trans-[Pt(N4CR)2(PTA)2] (R = Ph (4), 4-ClC6H4 (5) or 3-NC5H4 (6)), the reactions being greatly accelerated by microwave irradiation. 5-R-1H-Tetrazoles N4CR (R = Ph, 4-ClC6H4 and 3-NC5H4) were easily liberated from the tetrazolato complexes and isolated in high yields, in a single-pot process, upon reaction with aqueous diluted HCl, with concomitant formation of the water soluble cis-[Pt(Cl)2(PTA-H)2] complex 7. Alternatively, in a less convenient method, the tetrazoles could be liberated on reaction of 4-6 with propionitrile which also leads to the dicyano trans-[Pt(CN)2(PTA)2] complex 8. The compounds were characterized by IR, 1H, 13C and 31P[1H] NMR spectroscopies, FAB+-MS or ESI-MS, elemental analyses and (for and 4) also by X-ray diffraction.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
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Compuestos Organofosforados
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Azidas
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Tetrazoles
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Zinc
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Adamantano
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Agua
Idioma:
En
Revista:
Dalton Trans
Asunto de la revista:
QUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Portugal