Food hypersensitivity as a cause of rectal bleeding in adults.
Clin Gastroenterol Hepatol
; 7(1): 120-2, 2009 Jan.
Article
en En
| MEDLINE
| ID: mdl-19124116
ABSTRACT
BACKGROUND & AIMS:
Rectal bleeding and lymphonodular hyperplasia (LNH) in children can be caused by food hypersensitivity (FH). Our aim was to verify whether similar clinical and endoscopy presentations in adults can be due to FH.METHODS:
Consecutive adult patients with rectal bleeding were enrolled. All underwent routine assays, colonoscopy, and histology study.RESULTS:
Ten of 64 (15%) patients showed LNH as the unique sign at colonoscopy. An oligoantigenic diet resolved the rectal bleeding in 9 patients, and the reintroduction of several foods caused symptom reappearance. Double-blind placebo-controlled challenges with cow's milk and wheat protein confirmed the FH; symptoms reappeared 1-96 hours after the challenge. None of the patients were positive for IgE-mediated assays. In patients with LNH and FH, histology of the ileum and colon mucosa showed a higher number of lymphoid follicles and intraepithelial and lamina propria eosinophils compared with the other patients with rectal bleeding.CONCLUSIONS:
Recurrent rectal bleeding can be caused by FH in adult patients. Endoscopic evidence of LNH characterizes these cases.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedades del Recto
/
Hipersensibilidad a los Alimentos
/
Hemorragia
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Adult
/
Aged
/
Child
/
Humans
/
Middle aged
Idioma:
En
Revista:
Clin Gastroenterol Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Italia