Tumor bearing decreases systemic acute inflammation in rats--role of mast cell degranulation.
Inflamm Res
; 58(5): 235-40, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-19199089
ABSTRACT
OBJECTIVE AND DESIGN:
To investigate the effect of experimental tumor bearing on acute inflammation models in rats.METHODS:
Four and 7 days after Walker tumor implantation in the right armpit, carrageenan or dextran- induced edema in the contralateral paw, carrageenan induced neutrophil migration into peritoneal cavities, cutaneous vascular permeability induced by bradykinin, histamine, serotonin, substance P, capsaicin or compound 48/80, and mesenteric mast cell degranulation induced by compound 48/80 were evaluated. The control group did not receive tumor implantation. Statistical analysis was performed using one way analysis of variance (ANOVA) followed by the Bonferroni test.RESULTS:
On the 7(th) day after tumor inoculation, there were significant decreases in both carrageenan and dextran- induced paw edema. Tumor bearing did not change the neutrophil infiltration induced by carrageenan. There were decreases in cutaneous vascular permeability induced by compound 48/80, serotonin or bradykinin, but not that induced by histamine, substance P. A significant inhibition of mesenteric mast cell degranulation induced by compound 48/80 was observed, on the 4(th) and 7(th) days after tumor inoculation.CONCLUSION:
Tumor bearing can limit mast cell function and vascular events in acute systemic inflammation in rats, without changes in neutrophil migration.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Degranulación de la Célula
/
Inflamación
/
Mastocitos
/
Neoplasias
Límite:
Animals
Idioma:
En
Revista:
Inflamm Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Brasil