A phase II trial of triapine (NSC# 663249) and gemcitabine as second line treatment of advanced non-small cell lung cancer: Eastern Cooperative Oncology Group Study 1503.
Invest New Drugs
; 28(1): 91-7, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-19238328
ABSTRACT
BACKGROUND:
The objective of ECOG 1503 was to determine the response rate of this combination in the second-line treatment of advanced NSCLC.METHODS:
Triapine 105 mg/m(2) IV on days 1, 8, and 15, and gemcitabine 1,000 mg/m(2) on days 1, 8, and 15, of a 28 day cycle.RESULTS:
Eighteen patients enrolled. Three patients were not eligible due to protocol violations. No objective antitumor responses were seen. Three patients (20%) experienced stable disease (90% CI 5.7-44%). Median overall survival 5.4 months (95% CI 4.2-11.6 months); median time to progression 1.8 months (95% CI 1.7-3.5 months). Five patients developed acute infusion reactions to Triapine related to elevated methemoglobinemia. Patients with MDR1 variant genotypes of C3435T experienced superior overall survival compared to non-variants (13.3 vs. 4.3 months, respectively, p = 0.023).CONCLUSION:
This regimen did not demonstrate activity in relapsed NSCLC. Prolonged survival seen with MDR1 variant genotypes is hypothesis-generating.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
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Carcinoma de Pulmón de Células no Pequeñas
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Conducta Cooperativa
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Desoxicitidina
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Neoplasias Pulmonares
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Oncología Médica
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Antineoplásicos
Tipo de estudio:
Guideline
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Invest New Drugs
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos