Association of C-reactive protein and insulin resistance in patients with chronic spinal cord injury.
J Rehabil Med
; 40(10): 819-22, 2008 Nov.
Article
en En
| MEDLINE
| ID: mdl-19242618
ABSTRACT
OBJECTIVE:
To study the association between C-reactive protein levels and insulin resistance in patients with spinal cord injury.DESIGN:
Cross-sectional study.SUBJECTS:
Forty-two subjects who had sustained spinal cord injuries at least 6 months before enrollment.METHODS:
Circulating glucose, insulin and C-reactive protein levels were measured after 12 hours' fasting. The homeo-stasis model insulin resistance index was used to evaluate insulin resistance. Insulin resistance and C-reactive protein levels were compared between complete/incomplete patients and between paraplegic/tetraplegic patients. The subjects were then divided into 3 groups (C-reactive protein levels < 1, 1-3, > 3 mg/l) to compare insulin resistance.RESULTS:
Eighteen (43%) subjects had C-reactive protein levels > 3 mg/l. The C-reactive protein levels and insulin resistance did not significantly differ between complete/incomplete or between paraplegic/tetraplegic subjects. However, insulin resistance in the high C-reactive protein group (>3 mg/l) differed significantly from that of the other 2 groups, and there was a significant correlation between C-reactive protein and insulin resistance, with r=0.7745.CONCLUSION:
Most young and middle-aged patients with chronic spinal cord injury with high C-reactive protein levels also have high insulin resistance, and their C-reactive protein levels have well correlated with insulin resistance.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
/
Proteína C-Reactiva
/
Resistencia a la Insulina
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Rehabil Med
Asunto de la revista:
REABILITACAO
Año:
2008
Tipo del documento:
Article
País de afiliación:
Taiwán