Rosai-Dorfman disease presenting as a solitary mediastinal mass.
Pathol Int
; 59(4): 265-8, 2009 Apr.
Article
en En
| MEDLINE
| ID: mdl-19351372
ABSTRACT
Rosai-Dorfman disease (RDD) involving an extranodal site is a diagnostic challenge. Reported herein is the case of a 67-year-old man who presented with a solitary superior mediastinal mass. The lesion was clinically suspected of malignancy including lymphoma because of its high uptake during a (67)Ga-scintigram and (18)F-fluorodeoxyglucose-positron emission tomography. There was no evidence of spread of the disease. Histology of thoracoscopic biopsy specimens indicated granulomatous lesion with infiltration of lymphocytes, plasma cells, and histiocytes with lymphocytes engulfed in their cytoplasm. The lesion did not contain lymph node or thymic elements. On immunohistochemistry the histiocytes were positive for S-100 protein, CD68, and CD163 but were negative for CD1a. These findings suggested a diagnosis of RDD. Despite lack of intervention, the lesion remained almost the same size for 3 years. To the best of the authors' knowledge this is the first case of RDD presenting as a solitary mediastinal mass.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Histiocitosis Sinusal
/
Enfermedades del Mediastino
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Pathol Int
Asunto de la revista:
PATOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón