Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
Bioorg Med Chem Lett
; 19(10): 2646-9, 2009 May 15.
Article
en En
| MEDLINE
| ID: mdl-19376699
ABSTRACT
A new series of tricyclic-based inhibitors of IKK have been derived from an earlier lead compound. The synthesis and structure-activity relationships (SAR) are described. Compound 4k inhibited TNF production in rats stimulated with LPS.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pirimidinas
/
Inhibidores de Proteínas Quinasas
/
Quinasa I-kappa B
/
Imidazoles
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos