Novel pyridopyrimidine derivatives as inhibitors of stable toxin a (STa) induced cGMP synthesis.
Bioorg Med Chem Lett
; 19(11): 3067-71, 2009 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-19409779
ABSTRACT
A series of pyridopyrimidine derivatives were synthesized and evaluated for their ability to inhibit cyclic nucleotide synthesis in the presence of stable toxin a of Escherichia coli. The structure activity relationships around the basic core structure were examined and examples with better activity and potentially better pharmacological properties are presented.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pirimidinas
/
Toxinas Bacterianas
/
GMP Cíclico
/
Enterotoxinas
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos