Hunger and mood during extended fasting are dependent on the GNB3 C825T polymorphism.
Ann Nutr Metab
; 54(3): 184-8, 2009.
Article
en En
| MEDLINE
| ID: mdl-19420911
ABSTRACT
BACKGROUND/AIMS:
The 825T allele of the G protein beta3-subunit gene (GNB3) is a thrifty genotype associated with an increased risk for obesity. We aimed to determine whether the 825T allele is modifying the subjective response to extended fasting.METHODS:
We genotyped 108 subjects who underwent an 8-day modified medical fasting treatment [total energy intake <350 kcal (1465 kJ)/day] for the GNB3 C825T polymorphism. Perceived hunger and mood were recorded daily by self-rating visual analogue scales.RESULTS:
Whereas weight loss was not dependent on genotype, both mood and hunger were significantly associated with genotype, with homozygous CC genotype carriers having best mood (p = 0.004) and least hunger (p = 0.036) during fasting compared to TT genotype carriers.CONCLUSIONS:
Pronounced mental discomfort during fasting in 825T allele carriers might partly explain their increased risk for obesity. The strong association between the subjective response to fasting with GNB3 genotypes indicates a role of the gene in the behavioural regulation of food intake, which should be further considered in nutritional intervention studies.
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Ayuno
/
Hambre
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Afecto
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Proteínas de Unión al GTP Heterotriméricas
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Polimorfismo de Nucleótido Simple
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Nutr Metab
Año:
2009
Tipo del documento:
Article
País de afiliación:
Alemania