MEIS proteins as partners of the TLX1/HOX11 oncoprotein.
Leuk Res
; 34(3): 358-63, 2010 Mar.
Article
en En
| MEDLINE
| ID: mdl-19559479
ABSTRACT
Aberrant expression of the TLX1/HOX11 proto-oncogene is associated with a significant subset of T-cell acute lymphoblastic leukemias (T-ALL). Yet the manner in which TLX1 contributes to oncogenesis is not fully understood. Since, typically, interactions of HOX and TALE homeodomain proteins are determinant of HOX function, and HOX/MEIS co-expression has been shown to accelerate some leukemias, we systematically examined whether TLX1 interacts with MEIS and PBX proteins. Here, we report that TLX1 and MEIS proteins both interact and are co-expressed in T-ALL, and suggest that co-operation between TLX1 and MEIS proteins may have a significant role in T-cell leukemogenesis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Proteínas Proto-Oncogénicas
/
Proteínas de Homeodominio
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Leucemia-Linfoma Linfoblástico de Células T Precursoras
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Proteínas de Neoplasias
Límite:
Child
/
Humans
Idioma:
En
Revista:
Leuk Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Australia