Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
Bioorg Med Chem Lett
; 19(15): 4084-7, 2009 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-19559609
ABSTRACT
The transcription factor nuclear factor kappaB (NF-kappaB) induces the expression of various inflammatory genes. In the common NF-kappaB signaling pathway, peperomin E and 2,6-didehydropeperomin B inhibited IkappaB degradation upon stimulation with TNF-alpha or interleukin-1. Consistent with these results, peperomin E and 2,6-didehydropeperomin B blocked the TNF-alpha-induced activation of IkappaB kinase, while they had no direct effect on the IkappaB kinase activity. Our present results clearly demonstrate that peperomins inhibit the NF-kappaB signaling pathway by blocking IkappaB kinase activation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
FN-kappa B
/
Benzodioxoles
/
Inflamación
/
Antiinflamatorios
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón