The juxtamembrane region of EGFR takes center stage.
Cell
; 137(7): 1181-3, 2009 Jun 26.
Article
en En
| MEDLINE
| ID: mdl-19563749
ABSTRACT
The activation process for the epidermal growth factor receptor (EGFR) involves formation of an asymmetric dimer of the tyrosine kinase domains. Jura et al. (2009) in this issue and Brewer et al. (2009) in Molecular Cell now demonstrate that the juxtamembrane region of EGFR plays a crucial role in stabilizing this dimer.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Receptores ErbB
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Cell
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos